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Associate Professor
Department of Organic Chemistry
Indian Institute of Science, Bangalore 560012,INDIA
Tel: 2293-3380 Fax: 2360 0529
Email: eprabhak@iisc.ac.in

Education

  • PhD (2000): Indian Institute of Technology, Kanpur, U.P., India (Advisor: Prof. Javed Iqbal)
  • MSc (1995): Sri Sathya Sai Institute of Higher Learning, Prasantinilayam, Anantpur, AP, India (Thesis Advisor: Prof. K Anil Kumar)
  • BSc (1993): Sri Sathya Sai Institute of Higher Learning, Prasantinilayam, Anantpur, AP, India

Professional Positions

  • April 2006 to Present: Assistant Professor at the Department of Organic Chemistry, Indian Institute of Science, Bangalore, India
  • 2003 to 2006: Research Scientist at Texas A&M University, College Station, Texas, USA (Advisors: Prof. J. Martin Scholtz and C. Nick Pace)
  • 2000 to 2003: Postdoctoral Fellow at Indiana University, Bloomington, Indiana, USA (Advisor: Prof. Jeffrey N. Johnston)

Awards and Fellowships

  • “Best invention of the year” award by “Intellectual ventures”, USA (2008, 2009)  “The Most prolific inventor of Asia” award by “Intellectual ventures”, USA (2008, 2009)
  • NIH Postdoctoral Fellowship at Texas A&M University, College Station, Texas, USA (2003)
  • Boehringer Ingelheim Postdoctoral Fellowship from Indiana University, Bloomington, Indiana, USA (2000)
  • Best Student Award, for Overall Excellence in Academics (SSSIHL) (1993-95)
  • Guru Prasad University Gold Medal for Academic Excellence in Chemistry, at Sri Sathya Sai Institute of Higher Learning, Prasantinilayam, Anantpur, AP, India (1995)

We are a Chemical Biology group. The broad goals of our research are the design and synthesis of peptidomimetics as: 1) structural and functional mimics of biologically active motifs; 2) structural scaffolds and templates for propagation of peptide secondary structure and higher order structures; and 3) molecules for probing the structural and mechanistic principles in biological processes.  The design and characterization of the synthesized peptide-based constrained molecules involve an extensively integrated approach, where computational analysis, NMR, IR, CD, fluorescence and UV spectroscopy, calorimetry, chromatography and crystallography, are among the methods used.  The broad research areas that we research in, are listed below.

  • Synthesis of novel isosteres and amino acids
  • Chemical Biology
  • Protein and Peptide Engineering
  • Peptidomimetic design and peptide folding
  • Peptide-based supramolecular materials
  • Biosensors and detectors
  • Systematic Crystal Structure Analyses of cis X-Pro Containing Peptidomimetics: Understanding the Steric Interactions at the cis X-Pro Amide Bonds. Reddy, D. N., George, G., Prabhakaran, E. N. Angew. Chem. Int. Ed. Engl. 2013, in press.
  • A method for stabilizing the cis prolyl peptide bond: influence of an unusual n -> pi* interaction in 1,3-oxazine and 1,3-thiazine containing peptidomimetics. Reddy, D. N., Thirupathi, R., Tumminakatti, S., Prabhakaran, E. N. Tet. Lett. 2012, 53(33), 4413-4417.
  • Synthesis and Isolation of 5,6-Dihydro-4H-1,3- Oxazine Hydrobromides by Autocyclization of N-(3-Bromopropyl)amides. Reddy, D. N., Prabhakaran, E. N. J. Org. Chem., 2011, 76, 680–683.
  • Self-assembled microtubes and rhodamine 6G functionalized Raman-active gold microrods from 1-hydroxybenzotriazole. Thirupathi, R., Prabhakaran, E. N. J. Chem. Sci., 2011, 123(3), 247–254.
  • Accessing the disallowed conformations of peptides employing amide-to-imidate modification. Reddy, D. N., Thirupathi, R., Prabhakaran, E. N. Chem. Commun., 2011, 47, 9417–9419.
  • N-{1-[(3-Bromopropyl)aminocarbonyl]ethyl}-2-(2-nitrobenzenesulfonamido)propionamide. R. Tirupathy, D. N. Reddy, S. Brinda, E. N. Prabhakaran. Acta Cryst. E(65) 2009, o2308-o2309.
  • Protein structure, stability and solubility in water and other solvents. C. Nick Pace; Saul Trevino: Erode Prabhakaran; J. Martin Scholtz., Phil. Trans. R. Soc. Lond. B, 2004359 (1448), 1225-1234.
  • Free Radical-Mediated Aryl Amination and its Use in a Convergent -Amino Acid Synthesis.a[3+2] Strategy for Enantioselective Indoline  Viswanathan, Rajesh; Prabhakaran, Erode N.; Plotkin, Michael A.; Johnston, Jeffrey N., J. Am. Chem. Soc., 2003125, 163-168.
  • Free Radical Mediated Vinyl Amination: Access to N,N-Dialkyl Enamines and their b-Stannyl and b-Thio Derivatives. Prabhakaran, Erode N.; Nugent, Benjamin M.; Cox, Amie L.; Johnston, Jeffrey N., Org. Lett., 20024(24), 4197-4200.
  • Synthesis of Small Cyclic Peptides via Reverse Turn Induced Ring Closing Metathesis of Tripeptides. Prabhakaran, Erode N.; Rao, Nageshwara I.; Boruah, Anima; Iqbal, Javed, J. Org. Chem., 2002, 67, 8247-8250.
  • Nonconventional Carbon Additions to Azomethines. Aryl Amination/Indoline Synthesis by Direct Aryl Radical Addition to Azomethine Nitrogen. Johnston, Jeffrey N.; Plotin, Michael A.; Viswanathan, Rajesh; Prabhakaran, Erode N., Org. Lett., 20013, 1009-1010.
  • Polyaniline Supported Cobalt Catalyst: A Three Component Condensation Route to b-Amino Acid Derivatives. Prabhakaran, Erode N.; Iqbal, Javed, J. Org. Chem., 199964, 3339-3341.