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 Professor
Department of Organic Chemistry
Indian Institute of Science, Bangalore 560012,INDIA
Tel: 2293-2524; Fax: 23600529
Email: prasad@iisc.ac.in

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Education:

BSc:     Andhra University, Waltair (1989)
MSc:    Sri KrishnadevrayaUnivesrity, Anantapur (1991)
PhD:     National Chemical Laboratory, Pune 1997

Professional:

07/2014- Present Professor
Department of Organic Chemistry, Indian Institute of Science Bangalore, 560012, India
08/2008-07/2014 Associate Professor
Department of Organic Chemistry, Indian Institute of Science Bangalore, 560012, India
11/2003-08/2008  Assistant Professor
Department of Organic Chemistry, Indian Institute of Science Bangalore, 560012, India
03/2003- 10/2003 Research Scientist
Praecis Pharmaceuticals Inc (presently Glaxo Smith Kline) Waltham,MA.USA
08/ 2000- 03/2003 Post-Doctoral Fellow
Department of Chemistry, Temple University, Philadelphia, USA
10/ 1998- 6/ 2000 Alexander von Humboldt Foundation Fellow
Organisch-Chemisches Institut, Universität Münster, Germany

Honors and Awards

  • Fellow, Indian Academy of Sciences, 2015
  • Shanti Swarup Bhatnagar prize for chemical Sciences, 2014
  • Prof. N. S. Narasimhan Endowment Lecture Award, University of Pune 2013
  • Rajib Goyal Prize, 2012
  • Member, Editorial Advisory Board of Organic Lettersa premier journal in organic chemistry published by the American Chemical Society
  • NASI (National Academy of Sciences)-SCOPUS Young Scientist award
  • Swarnajayanthi fellowship of the Department of Science and Technology, New Delhi
  • Prof. ASR Anjaneyulu Endowment lectureship of the Indian Chemical Society
  • Alexander von Humboldt foundation post-doctoral fellowship, Federal Republic of Germany

 

The core theme of Prof. Prasad’s research is total synthesis of complex natural products of therapeutic significance with an emphasis on development of asymmetric synthetic strategies/ methodologies en route to the natural products. Some of the recent investigations include the total synthesis of complex macrolactones such as palmerolide A, tulearin C, iriomoteolide 3a, complex indole alkaloids such as eburnamonine, aspidospermidine and strychnine and triquinane natural products. Prof. Prasad’s group is also interested in developing bio-activity profile of the natural products and analogues with a particular interest in p53 protein; theprotein responsible for the control of many cellular processes.

Total synthesis of the bis-silyl ether of (+)-15-epi­-aetheramide A
Omkar, R.; Prasad, K. R. J. Org. Chem.2017, 82 (1), pp 438–460

Enantiospecific synthesis of functionalized polyols from tartaric acid using Ley’s dithiaketalization: Application to the total synthesis of achaetolide
Bali, A. K.; Sunnam, S. K.; Prasad, K. R. Tetrahedron, 2016, 72, 8623-8636.

Synthesis of β‑Amino-Substituted Enones by Addition of Substituted Methyl Enones to Sulfinimines: Application to the Total Synthesis of Alkaloids (+)-Lasubine II and (+)-241D and the Formal Total Synthesis of (−)-Lasubine I
Reddy, A. A.; Reddy, P. O.; Prasad, K. R. J. Org. Chem. 2016, 81, 11363−11371.

Synthesis and evaluation of C2-symmetric bis-sulfinamides as effective ligands in rhodium catalyzed addition of arylboronic acids to cycloalkenones
Revu, O.; Uphade, M. B.; Prasad, K. R. Tetrahedron, 2016, 72, 5355-5362.

Enantiospecific Formal Total Synthesis of Iriomoteolide 3a
Kumar, S. M.; Prasad, K. R. Chem. –Asian. J. 2014, 9, 3431.

Total synthesis of (+)-seimatopolide A
Prasad, K. R.; Omkar, R. J. Org. Chem. 2014, 79, 1461-1466.

An Unusual Ring Contraction Rearrangement Route to Functionalized Di and Triquinanes
Nagaraju, Ch.; Prasad, K. R. Angew. Chem. Int. Ed. 2014, 53, 10997.