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Assistant Professor
Tel: +91-80-2293-2042 (Office) / 2436 (Lab)
Fax: +91-80-2360-0529/0683
E-mail: md@iisc.ac.in
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Education:
MSc: Indian Institute of Technology, Bombay, India
PhD: University of Massachusetts, Amherst, MA, USA
Postdoctoral Research: at Northwestern University, Evanston, IL, USA

The research activities in our group involves:

  • Synthesis of layered molecular assemblies
  • Preparation of bilayer assemblies with various morphologies and reaction in bilayers
  • Synthesis of ligands for surface functionalization
  • Supramolecular interaction with biomolecules and their corresponding applications

We are interested in synthesis of laterally size controlled 2D single/thin-layer molecular assemblies by chemical synthesis/possessing (top-down/bottom-up method) from their corresponding precursors such as single molecular unit, single crystals etc. Followed by, we will explore the supramolecular application of these assemblies especially in molecular recognition such as protein, DNA and macromolecular interaction. The success of supramolecular application of various layered assemblies depends on the ability to fabricate surfaces with different functional groups by organic ligand synthesis which will be useful tools for molecular recognition. Following the synthesis, stabilization and surface functionalization of layered assemblies, we want to explore the various supramolecular applications including, but not limited to, molecular recognition, sensing and catalytic applications.

  • Towards non-invasive diagnostic imaging of early-stage Alzheimer’s disease” Viola, K. L.; Sbarboro, J.; Sureka, R.; De, M.; Bicca, M. A.; Wang, J.; Vasavada, S.; Satpathy, S.; Wu, S.; Joshi, H.; Velasco, P. T.; MacRenaris, K.; Waters, E. A.; Lu, C.; Phan, J.; Lacor, P.; Prasad, P.; Dravid V. P.; Klein, W. L. Nat. Nano., 2015, 10, 91-98
  • “Ligand conjugation of Chemically Exfoliated MoS2” Chou, S. S.; De, M.; Kim, J.; Byun, S.; Dykstra, C.; Yan, A.; Huang, J.; Dravid, V. P. J. Am. Chem. Soc., 2013, 135, 4584-4587.
  • ”Nanoscale Graphene Oxide (nGO) as Artificial Receptors: Implications for Biomolecular Interactions and Sensing” *Chou, S. S.; *De, M.; Luo, J.; Rotello, V. M.; Huang, J.; Dravid, V. P. J. Am. Chem. Soc., 2012, 134, 16725-16733.
  • “Graphene Oxide as an Enzyme Inhibitor: Modulation of Activity of a-Chymotrypsin” De, M.; Chou, S. S.; Dravid, V. P. J. Am. Chem. Soc., 2011, 133, 17524-17527.“Sensing of Serum Proteins in Human Serum using Nanoparticle-Green Fluorescence Protein Conjugates” De, M.; Rana, S.; Akpinar, H.; Miranda, O. R.; Arvizo, R. R.; Rotello, V. M. Nature Chem., 2009, 1, 461-465.
  • ”Intermolecular Electron-Transfer Catalyzed on Nanoparticle Surfaces” Carver, A. M.; De, M.; Bayraktar, H.; Rana, S. Rotello, V. M.; Knapp, M. J. J. Am. Chem. Soc., 2009, 131, 3798-3799.
  • “Synthetic chaperones : nanoparticle-mediated refolding of thermally denatured proteins” De, M.; Rotello, V. M. Chem. Commun., 2008, 3504-3506.
  • “Biomimetic Interactions of Proteins with Functionalized Nanoparticles” De, M.; You, C.-C.; Srivastava, S.; Rotello, V. M. J. Am. Chem. Soc,, 2007, 129, 10747-10753