Abstract– Protein-protein interactions (PPIs) are natural processes, which play a central role in most of the biological processes like- cell growth, cell signaling, cellular transport, morphology etc. Analysis of the known structure of protein-protein complexes, which are the results of protein-protein interactions are important lessons in order to understand the driving forces for protein-protein complexes. Protein-protein complexes varies not only in size, shape, contour and affinity but also these are of different types on the basis of architecture, binding, energies and lifetime of these quaternary structure. Not all the protein-protein interactions are important for our body, some of the wrong protein-protein interactions cause diseases (i.e. cervical cancer, bacterial infection, leukaemia etc.). Now the great challenges involves, how potentially we can inhibit these wrong protein-protein interactions. In the last 20 years, there is a sufficient progress in order to inhibit PPIs to give cause for optimism. Inhibition of these protein-protein interactions has been done by small molecule quite successfully but lot of works needs to be done to inhibit the protein-protein complexes. This presentation will give the brief introductory ideas of these crucial interactions and design of potential inhibitor (i.e. Nutlin) for the wrong protein-protein interactions.
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