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ABSTRACT: Heparin and Heparin sulfate are complex polysaccharides that modulate several biological events through the recognition of a number of proteins.Chemical synthesis is a powerful tool to identify the unique binding domains responsible for for specific interaction.Chemical synthesis of di-saccharides and conformationally constrained penta-saccharides will be discussed. Discussion will also be made on the structural features of heparin and heparan sulfate.

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