Abstract: The Suzuki-Miyaura(SM) reaction represents a powerful and general method for C – C bond formation in complex molecule synthesis. A simple and highly modular strategy has been reported for making small molecules using the Suzuki- Miyaura coupling iteratively which requires a ligand that can attenuate the reactivity of Boronic acids to withstand various SM conditions and then can be cleaved by mild reagents. This presentation aims to highlight a unified strategy for the construction of small molecules via the Iterative Suzuki coupling of Boron- protected Boronic acids – MIDA (N- Methyliminodiacidic acid) Boronate esters.
- Gillis, E. P.; Burke, M. D. Am. Chem. Soc. 2007 129, 6716-6717.
- Gillis, E. P.; Burke, M. D. Am. Chem. Soc. 2008 130, 14084-14085.
- Lee, S, J.; Gray, K. C.; Paek, J. S.; Burke, M. D. Am. Chem. Soc. 2008 130, 466-468