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Abstract: Frustrated Lewis pair (FLP) chemistry has emerged in the past decade as a powerful strategy that enables main-group compounds to activate small molecules.1 This concept is based on the notion that combination of Lewis acids and bases that are sterically prevented from forming classical Lewis acid-base adducts have Lewis acidity and basicity available for interaction with a third molecule. This concept has been applied to stoichiometric reactivity and then extended to catalysis. Frustrated Lewis pair heterolytically activates the molecular hydrogen, which forms the basis of their use as a metal-free hydrogenation catalyst. This concept has been employed in the hydrogenation of several organic molecules including imines,2 carbonyls,3 unsaturated molecules4 and even in reduction of CO2.5 This presentation focuses on the recent developments in the field of frustrated Lewis pair catalysis.

References:

  1. (a) Stephan, D. W.; Erker, G. Angew. Chem., Int. Ed. 2010, 49, 46, (b) Stephan, D. W,; Erker, G. Chem. Sci. 2014, 5, 2625, (c) Stephan, D. W.; Erker, G. Angew. Chem., Int. Ed. 2015, 54, 6400.
  2. Chase,P. A,; Welch,G. C,; Jurca, T,; Stephan, D. W. Angew. Chem. Int. Ed. 2007, 46, 8050.
  3. Mahdi, T,;Stephan, D. W. J. Am. Chem. Soc. 2014, 136,15809.
  4. Chernichenko, K.; Madarasz, A.; Papai, I.; Nieger, M.; Leskela, M.; Repo, T. Nat. Chem. 2013, 5, 718, (b) Paradies, J. Angew. Chem. Int. Ed. 2014, 53, 3552.
  5. Dobrovetsky, R.; Stephan, D. W. Angew. Chem., Int. Ed. 2013, 52, 2516.